Tetrahydrofuran → N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-4-methyl-1,3-oxazole-5-carboxamide

Participants

Reaction Steps

In the same manner as in Example 18-4 and using 4-methyl-1,3-oxazole-5-carboxylic acid (410 mg, 3.22 mmol), tetrahydrofuran (10 mL), oxalyl chloride (420 μL, 4.84 mmol), N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (200 mg, 0.647 mmol), N,N-dimethylformamide (2 drops) and N,N-dimethylacetamide (10 mL) as starting materials, the title compound (102 mg, 38%) was obtained as a white solid.

Provenance & Evidence