Cyclopropanecarbonyl chloride → HCID 57749407, compound

Participants

Reaction Steps

To a solution of tert-butyl {5-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-2-methylphenyl}carbamate (3.52 g, 8.92 mmol) in N,N-dimethylacetamide (30 mL) was added cyclopropanecarbonyl chloride (0.811 mL, 8.93 mmol) at 0° C., and the mixture was stirred at room temperature for 84 hr. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography (silica gel, hexane/ethyl acetate=100/0→425/75) to give the title compound (3.87 g, 97%) as a colorless oil.

Provenance & Evidence