Tetrahydrofuran → N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide

Participants

Reaction Steps

In the same manner as in Example 55 and using 1-methyl-1H-pyrazole-5-carboxylic acid (86.0 mg, 0.686 mmol), tetrahydrofuran (5 mL), thionyl chloride (118 μL, 1.36 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (200 mg, 0.619 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (125 mg, 47%) was obtained as a white solid.

Provenance & Evidence