HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 57749164, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Cyclopentene-1-carboxylic acid | HCID 853756 | — |
| Reactant | N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | HCID 57749401 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 57749164 | HCID 57749164 | 59.2% |
Reaction Steps
In the same manner as in Example 55 and using cyclopenta-3-en-1-carboxylic acid (66.0 mg, 0.592 mmol), tetrahydrofuran (5 mL), thionyl chloride (100 μL, 1.15 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (170 mg, 0.526 mmol) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (130 mg, 59%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304557B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-b8f6780c4eef4e658136b8ede133d184 |
| Source note | uspto-grants-2012_11 |