Tetrahydrofuran → N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide

Beteiligte Stoffe

Reaktionsschritte

In the same manner as in Example 55 and using 1,3-dimethyl-1H-pyrazole-4-carboxylic acid (67.0 mg, 0.478 mmol), tetrahydrofuran (5 mL), thionyl chloride (83.0 μL, 0.957 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (140 mg, 0.433 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (112 mg, 58%) was obtained as a pale-brown solid.

Herkunft & Nachweise