HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 57749123, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Methylpicolinic acid | HCID 268757 | — |
| Reactant | HCID 57387081 | HCID 57387081 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 57749123 | HCID 57749123 | 77% |
Reaction Steps
In the same manner as in Example 18-4 and using 3-methylpyridine-2-carboxylic acid (132 mg, 0.965 mmol), tetrahydrofuran (8 mL), oxalyl chloride (169 μL, 1.93 mmol), N-[5-(3-aminophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide (210 mg, 0.643 mmol), N,N-dimethylformamide (1 drop) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (220 mg, 77%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304557B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-bdbfb0348fa946f9a605fc336f5f1d96 |
| Source note | uspto-grants-2012_11 |