反应详情

温度

100 °C

A mixture of N-[6-(3-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide (19.7 mg, 0.064 mmol), benzene-1,2-dicarbaldehyde (10.7 mg, 0.080 mmol) and acetic acid (4.0 mL) was stirred at 100° C. for 13 hr. The reaction mixture was concentrated under reduced pressure, and ethyl acetate was added to the residue. The mixture was washed with aqueous sodium hydrogen carbonate solution and saturated brine. The organic layer was concentrated, and the residue was purified by preparative HPLC to give the title compound (4.8 mg, 18%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, and ethyl acetate
2. additionwas added to the residue
3. washThe mixture was washed with aqueous sodium hydrogen carbonate solution and saturated brine
4. concentrationThe organic layer was concentrated
5. customthe residue was purified by preparative HPLC