Benzenesulfonyl chloride → HCID 57749183, compound

Participants

Reaction Steps

A mixture of N-[6-(3-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide (18.6 mg, 0.060 mmol), benzenesulfonyl chloride (12.8 μL, 0.100 mmol), tetrahydrofuran (3 mL) and aqueous sodium hydrogen carbonate solution (2 mL) was stirred at room temperature for 4 hr. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated, and the residue was purified by preparative HPLC to give the title compound (10.9 mg, 41%).

Provenance & Evidence