Water → HCID 57749134, compound

Participants

Reaction Steps

To a solution of N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide (203 mg, 0.477 mmol) in pyridine (10 mL) was added 2-chloro-2-oxoethyl acetate (103 μL, 0.954 mmol), and the mixture was stirred at room temperature for 17 hr. The reaction solution was concentrated under reduced pressure, and the residue was dissolved in methanol (10 mL). Potassium carbonate (132 mg, 0.954 mmol) was added thereto, and the mixture was stirred at room temperature for 1 hr. Water (30 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (50 mL, 2×10 mL). The combined organic layer was washed with saturated brine (10 mL) and dried over anhydrous sodium sulfate. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. Ethyl acetate and diisopropyl ether were added to the obtained residue. The obtained precipitate was collected by filtration and dried to give the title compound (182 mg, 79%) as a colorless powder.

Provenance & Evidence