HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Chloro-N-(4-(methyloxy)-1-{[3-(methyloxy)phenyl]methyl}-1H-indazol-3-yl)-2-thiophenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Methoxybenzyl bromide | HCID 4067207 | — |
| Reactant | 5-chloro-N-[4-(methyloxy)-1H-indazol-3-yl]-N-({[2-(trimethylsilyl)ethyl]oxy}methyl)-2-thiophenesulfonamide | HCID 58054443 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-N-(4-(methyloxy)-1-{[3-(methyloxy)phenyl]methyl}-1H-indazol-3-yl)-2-thiophenesulfonamide | HCID 59455992 | — |
Reaction Steps
Was prepared by alkylation of 5-chloro-N-[4-(methyloxy)-1H-indazol-3-yl]-N-({[2-(trimethylsilyl)ethyl]oxy}methyl)-2-thiophenesulfonamide (for a preparation see Intermediate 8) with 3-methoxybenzyl bromide and potassium carbonate in DMF as above. LCMS (System A) RT=1.25 min, ES+ve m/z 464/466 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304446B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-dd32774c0aea453b808f29ecf3ce8c1e |
| Source note | uspto-grants-2012_11 |