2-Chloro-5-methylphenol → 1-Chloro-2-methoxy-4-methylbenzene

Participants

Reaction Steps

2-Chloro-5-methylphenol (5.0 g, 35.0 mmol) was dissolved in 50% CH2Cl2/methanol (100 mL) and trimethylsilyl diazomethane (2.0 M in hexanes, 25 mL) was added dropwise until a persistent yellow color was observed. The solution was stirred overnight. The solvent was evaporated and the crude product was purified by column chromatography (hexane/EtOAc) to afford the title compound (3.0 g, 55%) as an oil. 1H NMR (400 MHz, DMSO-d6): δ ppm 7.25 (d, 1H), 6.95 (d, 1H), 6.74 (dt, 1H), 3.81 (s, 3H), 2.28 (s, 3H).

Provenance & Evidence