Trifluoroacetic acid → HCID 178503477, compound

Participants

Reaction Steps

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-(methylthio)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide trifluoroacetate (0.030 g, 0.04 mmol) was dissolved in CH2Cl2 (2 mL) and trifluoroacetic acid (2 mL) and stirred for 2 h. The solvent was evaporated. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA). The desired fractions were lyophilized to afford the title compound (0.017 g, 70%) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ ppm 8.57 (t, 1H), 7.79 (s, 1H), 7.68 (s, 1H), 7.43-7.52 (m, 3H), 7.30 (t, 1H), 4.45 (d, 2H), 2.55 (s, 3H). MS: m/z 451.0 (M+1).

Provenance & Evidence