Diisopropylethylamine → HCID 178509934, compound

Participants

Reaction Steps

In a 1 dram vial, 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (25 mg, 0.080 mmol), DIPEA (0.014 mL, 0.080 mmol) and 1H-pyrazole-3-carboxylic acid (9.01 mg, 0.080 mmol) were dissolved in DMF (1 mL). HATU was added (30.6 mg, 0.080 mmol) and the solution stirred overnight. The reaction mixture was diluted to 2 mL with MeOH. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA) to afford the title compound (0.016 g, 50%) as a white solid. 1H NMR (400 MHz, Acetone-d6): δ ppm 8.11 (br. s., 1H), 7.79 (d, 1H), 7.62 (t, 1H), 7.36-7.46 (m, 4H), 6.75 (d, 1H), 4.59-4.69 (m, 2 H). LCMS m/z 404.9 (M+1).

Provenance & Evidence