Diisopropylethylamine → HCID 59451386, compound

Participants

Reaction Steps

In a 1 dram vial, 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (25 mg, 0.080 mmol), DIPEA (0.014 mL, 0.080 mmol) and 5-chloro-2-(methylthio)-4-pyrimidinecarboxylic acid (16.44 mg, 0.080 mmol) were dissolved in DMF (1 mL). HATU was added (30.6 mg, 0.080 mmol) and the solution stirred overnight. The reaction mixture was diluted to 2 mL with MeOH. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA) to afford the title compound (0.017 g, 38%) as a white solid. 1H NMR (400 MHz, Acetone-d6): δ ppm 8.73-8.81 (m, 2H), 7.63 (t, 1H), 7.47-7.54 (m, 1H), 7.42-7.47 (m, 1H), 7.36-7.41 (m, 2H), 4.69 (d, 2H), 2.56 (br. s., 3H). LCMS m/z 496.9 (M+1).

Provenance & Evidence