Diisopropylethylamine → 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate

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Reaction Steps

HATU (0.064 g, 0.168 mmol) was added to a solution of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.035 g, 0.112 mmol), 5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylic acid (0.032 g, 0.116 mmol), and DIPEA (0.030 ml, 0.168 mmol) in DMF (1 mL). The mixture was stirred at RT for 1.5 h. Water and EtOAc were added. The organic layer was separated and washed with water and brine, dried over sodium sulfate, and concentrated to give the title compound (0.038 g, 60%) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ ppm 9.67 (s, 1H), 7.75 (s, 1H), 7.17-7.37 (m, 4H), 7.14 (t, 1H), 7.08 (dd, 1H), 6.94-7.02 (m, 2H), 6.80 (m, 1H), 6.60 (s, 1H), 4.69 (d, 2H), 1.52 (m, 9H). MS: m/z 569 (M).

Provenance & Evidence