HCID 178450789, compound → HCID 178450788, compound

Participants

Reaction Steps

Platinum(IV) oxide (0.020 g, 0.090 mmol) was added to a suspension of 1,1-dimethylethyl 5-nitro-1H-benzimidazole-2-carboxylate (0.472 g, 1.793 mmol) in ethanol (20 mL) in a pressure vessel. The mixture was evacuated and flushed with nitrogen, then evacuated and flushed with hydrogen (50 Psi). After 1 h, the reaction mixture was filtered through Celite. The filtrate was concentrated and the residue was dried under vacuum to give the title compound (0.359 g, 69%) as a yellow solid. 1H NMR (400 MHz, CDCl3): δ ppm 10.03 (s, 1H), 7.66 (d, 1H), 6.49-6.90 (m, 2H), 3.77 (br. s., 2H), 1.64 (s, 9H). MS: m/z 234 (M+1).

Provenance & Evidence