(5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol → HCID 178437660, compound

Participants

Reaction Steps

A solution of (4-chloro-2-ethyl-1H-imidazol-5-yl)methanol (1.60 g, 10.0 mmol) and manganese dioxide (5.5 g, 63.3 mmol) in CH2Cl2 (30 mL) and 1,4-dioxane (15 mL) was heated under reflux for 6.5 h. The reaction mixture was cooled to RT, then filtered through Celite, which was washed thoroughly with CH2Cl2. The filtrate was concentrated and dried to provide the title compound (0.763 mg, 48%) as a pale yellow solid. 1H NMR (400 MHz, CDCl3) δ ppm 9.66 (s, 1H), 2.84 (q, 2H), 1.38 (t, 3 H).

Provenance & Evidence