Water → HCID 68485937, compound

Participants

Reaction Steps

3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-5-bromobenzonitrile (2.04 g, 5.35 mmol) dissolved in THF (30 mL) was treated successively with triphenylphosphine (2.10 g, 8.02 mmol) and water (0.482 g, 26.7 mmol) at 25° C. for 16 h with stirring. The reaction mixture was concentrated to dryness and purified on silica gel (eluted successively with EtOAc (to remove triphylphosphine oxide) followed by a gradient of 100% EtOAc to 10% CH3OH/DCM) to give 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-bromobenzonitrile (1.12 g, 3.15 mmol, 58.9% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.92 (t, 1H), 7.46-7.57 (m, 4H), 3.77 (s, 2H), 1.91 (br. s., 2H). LC-MS (ES+) m/z 354.92, 356.91, 358.88 [M+H].

Provenance & Evidence