Chlorosuccinimide → HCID 68486489, compound

Participants

Reaction Steps

NCS (0.048 g, 0.358 mmol) was added to a DMF (2 mL) solution of ethyl 5-{[2-(methylthio)ethyl]oxy}-1H-indole-2-carboxylate (0.100 g, 0.358 mmol) and the reaction mixture stirred over the weekend at room temperature. The reaction mixture was partitioned between water and EtOAc and the organic layer was separated. The organic layer was dried over MgSO4, filtered and evaporated onto silica. Purification was accomplished by silica gel column chromatography (0-50% EtOAc/hexanes) to afford the title compound (0.067 g, 71%) as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 9.38 (br. s., 1H), 7.11 (s, 1H), 7.04 (d, 1H), 6.85 (d, 1H), 4.35-4.47 (m, 4 H), 3.16-3.24 (m, 2H), 1.41 (t, 3H). LCMS: m/z=264 (M+1).

Provenance & Evidence