Diisopropylethylamine → HCID 59451603, compound

Participants

Reaction Steps

HATU (0.061 g, 0.161 mmol) was added as a solid to a solution of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.050 g, 0.161 mmol), 2,3-dihydro-7H-[1,4]oxathiino[3,2-e]indole-8-carboxylic acid (0.038 g, 0.161 mmol) and DIPEA (0.028 mL, 0.161 mmol) in DMF (1 mL). After 2 hours the reaction mixture was poured into EtOAc and water and the organic layer separated. The organic layer was dried over MgSO4, filtered and the solvent evaporated. The residue was dissolved in MeOH and purification was accomplished by reverse-phase HPLC (water/acetonitrile with 0.1% TFA) to afford the title compound (0.032 g, 38%) as a white solid. 1H NMR (400 MHz, Acetone-d6) δ ppm 10.76 (br. s., 1H), 8.36 (t, 1H), 7.64 (t, 1H), 7.42-7.52 (m, 2H), 7.39-7.42 (m, 2H), 7.20 (dd, 1H), 7.00 (dd, 1H), 6.77 (d, 1H), 4.70 (d, 2H), 4.38-4.43 (m, 2H), 3.23-3.28 (m, 2H). LCMS: m/z=528.0 (M+1).

Provenance & Evidence