HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → methyl 3-chloro-4-[(dimethylamino)carbonyl]-1H-pyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-chloro-5-[(methyloxy)carbonyl]-1H-pyrrole-3-carboxylic acid | HCID 68486211 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | methyl 3-chloro-4-[(dimethylamino)carbonyl]-1H-pyrrole-2-carboxylate | HCID 68487372 | 49.5% |
Reaction Steps
To a solution of 4-chloro-5-[(methyloxy)carbonyl]-1H-pyrrole-3-carboxylic acid (0.075 g, 0.368 mmol) in DMF (1 ml) was added HATU (0.168 g, 0.442 mmol), DIPEA (0.097 ml, 0.553 mmol) and dimethyl amine (2M in THF) (0.276 ml, 0.553 mmol) and the reaction stirred at RT for 1 h. Purification was accomplished by HPLC to afford methyl 3-chloro-4-[(dimethylamino)carbonyl]-1H-pyrrole-2-carboxylate (0.042 g, 49% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.40 (br. s., 1H) 7.23 (d, 1H) 3.80 (s, 3H) 2.93 (s, 6H). MS: m/z 231.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304419B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-acc59fe774714ce780319e1c84443d50 |
| Source note | uspto-grants-2012_11 |