Trifluoroacetic acid → 5-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate

Participants

Reaction Steps

Trifluoroacetic acid (5 mL, 64.9 mmol) was added to a solution of 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate (1.36 g, 2.39 mmol) in dichloromethane (40 mL). The reaction mixture was stirred at RT overnight. The solvent was evaporated to give the title compound as a beige foam (1.35 g, 97%). 1H NMR (400 MHz, DMSO-d6) δ ppm 11.94 (s, 1H), 9.92 (br. s., 2H), 9.13 (t, 1H), 7.75-7.85 (m, 1H), 7.62 (d, 1H), 7.44-7.57 (m, 4H), 7.40 (t, 1H), 7.23 (d, 1H), 7.16 (dd, 1H), 4.57 (d, 2H). ES-LCMS: m/z 469 (M+H).

Provenance & Evidence