HCID 59451573, compound → HCID 59451503, compound

Participants

Reaction Conditions

Reaction Steps

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-6-({3-[(1,1-dimethylethyl)oxy]propanoyl}amino)-1H-indole-2-carboxamide (0.049 g, 0.082 mmol) was dissolved in 4N HCl in dioxane (3 mL). The mixture was heated in a 105° C. oil bath under a reflux condenser for 3 days. The solvent was evaporated and the residue was purified by reverse phase HPLC (acetonitrile:water with 0.1% TFA) to give the title compound (0.009 g, 20%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.48 (br. s., 1H), 9.82 (s, 1H), 8.69-9.06 (m, 1H), 7.91-7.99 (m, 1H), 7.78 (s, 1H), 7.42-7.56 (m, 4H), 7.35 (t, 1H), 7.08 (d, 2H), 4.30-4.70 (m, 2H), 3.54-3.82 (m, 2H), 2.39-2.46 (m, 2H). ES MS: m/z 541 (M+1).

Provenance & Evidence