反应详情

温度

90 °C

Copper(I) oxide (1.258 g, 8.79 mmol) was added to a solution of [2-fluoro-3-(1-naphthalenyloxy)-4-nitrophenyl]acetic acid (15.70 g, 46 mmol) in acetonitrile (200 mL). The mixture was heated at 90° C. for 4 hrs. The reaction mixture was concentrated and the residue was purified by flash chromatography (hexane:ethyl acetate) to give the title compound (6.30 g, 36%). ES MS: m/z 298 (M+1), ˜80% pure.

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by flash chromatography (hexane:ethyl acetate)