2-azido-N-({4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-chloro-1H-imidazole-5-carboxamide → HCID 178509908, compound

Participants

Reaction Steps

Lindlar Catalyst (0.167 g, 0.078 mmol) was added to a suspension of 2-azido-N-({4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-chloro-1H-imidazole-5-carboxamide (0.824 g, 1.569 mmol) in ethyl acetate (30 mL) in a pressure vessel. The vessel was evacuated and flushed with nitrogen, then evacuated and filled with hydrogen (50 psi). The reaction mixture was stirred for 7 h, then filtered through celite. The filtrate was evaporated to dryness and the residue was triturated with ethanol and dried under vacuum to give the title compound (0.350 g, 44%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.95 (br. s., 1H), 7.80 (s, 1H), 7.76 (t, 1H), 7.60 (d, 1H), 7.48 (s, 1H), 7.42 (m, 1H), 7.26 (t, 1H), 5.79 (br. s., 2H), 4.45 (d, 2H). ES MS m/z 498 (M−H).

Provenance & Evidence