Pyrrole-2-Carboxylic Acid → N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-N-ethyl-1H-pyrrole-2-carboxamide

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Reaction Steps

DMF (3 mL) and DIPEA (0.1 mL, 0.59 mmol) were added to a mixture of HATU (0.12 g, 0.32 mmol), 3-chloro-5-({6-chloro-3-[(ethylamino)methyl]-2-fluorophenyl}oxy)benzonitrile (0.10 g, 0.29 mmol) and 1H-pyrrole-2-carboxylic acid (0.05 g, 0.41 mmol). The yellow solution was stirred at RT under a nitrogen atmosphere for 48 h then ethyl acetate (100 ml) and saturated NaHCO3 solution (100 ml) were added. The organic layer was washed with saturated NaHCO3 solution (2×100 ml), brine (150 mL), dried over MgSO4, filtered and concentrated. The crude material was purified by Reverse Phase HPLC (MeCN/water+0.1% TFA) to give the title compound (0.039 g, 31%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.51 (s, 1H), 7.82 (br. s., 1H), 7.08-7.68 (m, 3H), 6.74-7.04 (m, 1H), 6.24-6.62 (m, 1H), 6.12 (d, 1H), 4.56-5.10 (m, 2H), 3.54-3.88 (m, 2H), 0.96-1.45 (m, 3H). LCMS m/z 433.9 (M+H).

Provenance & Evidence