Diisopropylethylamine → HCID 178432444, compound

Participants

Reaction Steps

DMF (5 mL) was added to a mixture of 3-{[5-(aminomethyl)-2-chlorophenyl]oxy}-5-chlorobenzonitrile hydrochloride (0.125 g, 0.379 mmol), 4-bromo-2-methyl-1H-imidazole-5-carboxylic acid (0.093 g, 0.455 mmol) and HATU (0.173 g, 0.455 mmol). The mixture was stirred for 5 min then DIPEA (0.132 ml, 0.758 mmol) was added and the yellow solution was stirred at RT under an atmosphere of nitrogen for 2 h. Saturated aqueous NaHCO3 solution (30 mL) and Et2O (10 mL) was added and the suspension was filtered to give 0.50 g of an insoluble white solid. The filtrate was extracted with ethyl acetate (75 mL) and washed with saturated aqueous Na HCO3 solution (2×50 mL), water (50 mL), brine (50 mL), dried over MgSO4, filtered and concentrated. The crude material was purified on silica gel (hexanes/ethyl acetate) to give the title compound (0.075 g, 41%) in ca. 70% purity. The material was purified further by Reverse Phase HPLC (MeCN/H2O+0.1% TFA) to give the title compound (0.043 g, 24%) as a white powder. 1H NMR (400 MHz, DMSO-d6+CD3OD) δ ppm 7.66 (br. s., 1H), 7.54 (d, 1H), 7.16-7.35 (m, 4H), 4.44 (br. s., 2H), 2.25 (s, 3H). LCMS m/z 481.0 (M+H).

Provenance & Evidence