Trifluoroacetic acid → HCID 178510917, compound

Participants

Reaction Steps

To a solution of 4-chloro-N-{[4-chloro-3-({3-chloro-5-[(E)-2-cyanoethenyl]phenyl}oxy)-2-fluorophenyl]methyl}-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide (106 mg, 0.178 mmol) in DCM (5 ml) was added TFA (2.0 mL) and the reaction mixture was stirred at room temperature for 6 hours. The solvent was removed and the crude material was purified via reverse phase HPLC to give 4-chloro-N-{[4-chloro-3-({3-chloro-5-[(E)-2-cyanoethenyl]phenyl}oxy)-2-fluorophenyl]methyl}-1H-imidazole-5-carboxamide (72 mg, 0.155 mmol, 87% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.81-13.40 (m, 1H), 8.08-8.51 (m, 1H), 7.72 (s, 1H), 7.51-7.62 (m, 2H), 7.45 (d, 1H), 7.31 (t, 1H), 7.23 (s, 1H), 7.00 (s, 1H), 6.58 (d, 1H), 4.48 (d, 2H). LC-MS (ES+) m/z 464.94, [M+H].

Provenance & Evidence