1,2-Dichloroethane → HCID 178432869, compound

Participants

Reaction Steps

To a solution of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-bromobenzonitrile (900 mg, 2.53 mmol) and 4-chloro-2-methyl-1H-imidazole-5-carboxylic acid (813 mg, 2.53 mmol) in DMF (10 ml) was added HOBT (388 mg, 2.53 mmol) and EDC (485 mg, 2.53 mmol) and the reaction mixture was stirred for 6 hours at rt. The reaction mixture was diluted with EtOAc and washed with water. The solvent was removed and the crude material was purified via silica gel chromatography to give N-({3-[(3-bromo-5-cyanophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-4-chloro-2-methyl-1H-imidazole-5-carboxamide (0.560 g, 1.124 mmol, 44% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.68 (s, 1H), 7.29-7.45 (m, 3H), 7.25 (s, 1H), 4.63 (s, 2H), 2.34 (s, 3H). LC-MS (ES+) m/z 496.87, [M+H].

Provenance & Evidence