Azobisisobutyronitrile → HCID 86644945, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[(3-bromo-2-chloro-6-fluoro-5-methylphenyl)oxy]-5-chlorobenzonitrile (2.74 g, 7.31 mmol) and NBS (1.300 g, 7.31 mmol) in carbon tertrachloride (200 ml) was added AIBN (0.060 g, 0.365 mmol) and the reaction mixture was stirred at 80° C. overnight. The solvent was removed and the crude material was purified via silica gel chromatography to give the title compound 3-{[3-bromo-5-(bromomethyl)-2-chloro-6-fluorophenyl]oxy}-5-chlorobenzonitrile (1.04 g, 1.604 mmol, 22% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.01 (d, 1H), 7.79 (s, 1H), 7.58 (s, 2H), 4.68 (s, 2H)

Provenance & Evidence