Trifluoroacetic acid → HCID 178510240, compound

Participants

Reaction Steps

To a solution of 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(difluoromethyl)phenyl]oxy}-2-fluorophenyl)methyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide (81 mg, 0.138 mmol) dissolved in DCM (5 ml) was added TFA (2.00 ml) and the reaction mixture was stirred at RT for 2 hours. The solvent was removed and the crude material was purified via reverse phase HPLC to give 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(difluoromethyl)phenyl]oxy}-2-fluorophenyl)methyl]-1H-imidazole-5-carboxamide (56 mg, 0.123 mmol, 89% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.77 (s, 1H), 7.65 (s, 1H), 7.23-7.50 (m, 4H), 6.81 (t, 1H), 4.64 (s, 2H). LC-MS (ES+) m/z 454.97, [M+H].

Provenance & Evidence