Trifluoroacetic acid → HCID 178436597, compound

Participants

Reaction Steps

To a solution of 4-chloro-N-({4-chloro-3-[(3-cyano-5-ethynylphenyl)oxy]-2-fluorophenyl}methyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide (44.0 mg, 0.079 mmol) in DCM (6 ml) was added TFA (2.0 mL) and the reaction mixture was stirred at rt for one hour. The solvent was removed and the crude material was purified via reverse phase HPLC to give 4-chloro-N-({4-chloro-3-[(3-cyano-5-ethynylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide (23 mg, 0.042 mmol, 54% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.72 (s, 1H), 7.53 (s, 1H), 7.29-7.40 (m, 2H), 7.25 (s, 1H), 7.20 (s, 1H), 4.63 (s, 2H), 3.74 (s, 1H). LC-MS (ES+) m/z 429.00, [M+H].

Provenance & Evidence