Trifluoroacetic acid → HCID 178461130, compound

Participants

Reaction Steps

To a solution of 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(1,1-difluoroethyl)phenyl]oxy}-2-fluorophenyl)methyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide (59 mg, 0.098 mmol) in DCM (6 ml) was added TFA (2.0 mL) and the reaction mixture was stirred at RT for 3 hours. The reaction mixture was purified via reverse phase HPLC to give 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(1,1-difluoroethyl)phenyl]oxy}-2-fluorophenyl)methyl]-1H-imidazole-5-carboxamide (28 mg, 0.060 mmol, 61% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.72 (s, 1H), 7.63 (s, 1H), 7.30-7.42 (m, 3H), 7.28 (s, 1H), 4.63 (s, 2H), 1.90 (t, 3H). LC-MS (ES+) m/z 469.08, [M+H].

Provenance & Evidence