Propyne → HCID 178439241, compound

HRID 1875194Notes

Reaction equation

HRID 1875194 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:10][C:11]2[C:12]([F:28])=[C:13]([CH2:18][NH:19][C:20]([C:22]3[NH:26][CH:25]=[N:24][C:23]=3[Cl:27])=[O:21])[CH:14]=[CH:15][C:16]=2[Cl:17])[CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.[CH:29]#[C:30][CH3:31]>C1COCC1.[Cu]I>[Cl:27][C:23]1[N:24]=[CH:25][NH:26][C:22]=1[C:20]([NH:19][CH2:18][C:13]1[CH:14]=[CH:15][C:16]([Cl:17])=[C:11]([O:10][C:4]2[CH:3]=[C:2]([C:29]#[C:30][CH3:31])[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=2)[C:12]=1[F:28])=[O:21]

Participants

5

Reactant 2

HCID 6335PropyneHCID 178509438HCID 178509438, compound

Product 1

HCID 178439241HCID 178439241, compoundYield 45%

Reagents, catalysts & solvents 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N-({3-[(3-bromo-5-cyanophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-4-chloro-1H-imidazole-5-carboxamide (70.0 mg, 0.145 mmol), Palladium dichlorobistriphenylphosphine(II) (7.55 mg, 0.014 mmol), copper(I)iodide (1.377 mg, 7.23 μmol) and TEA (0.101 ml, 0.723 mmol) in THF (4 ml) was bubbled 1-propyne (11.59 mg, 0.289 mmol) for 5 minutes and the reaction mixture was irradiated in a personal microwave reactor for 10 minutes at 120° C. The solvent was removed and the crude material was purified via reverse phase HPLC to give 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(1-propyn-1-yl)phenyl]oxy}-2-fluorophenyl)methyl]-1H-imidazole-5-carboxamide (29 mg, 0.065 mmol, 45% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.60-7.81 (m, 1H), 7.40 (s, 1H), 7.28-7.38 (m, 3H), 7.16 (s, 1H), 7.05 (s, 1H), 4.62 (s, 2H), 1.99 (s, 3H). LC-MS (ES+) m/z 443.13, [M+H].

Workup

  1. customthe reaction mixture was irradiated in a personal microwave reactor for 10 minutes at 120° C
  2. customThe solvent was removed
  3. customthe crude material was purified via reverse phase HPLC

Sources & evidence

ORD record
ord-59ed5119403a42d889a9c0d8f9a3db68
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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