Trifluoroacetic acid → 3-{[3-(Aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-(difluoromethyl)benzonitrile trifluoroacetate

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl[(4-chloro-3-{[3-cyano-5-(difluoromethyl)phenyl]oxy}-2-fluorophenyl)methyl]carbamate (210 mg, 0.492 mmol) in DCM (10 ml) was added TFA (3.0 mL, 38.9 mmol) and the reaction mixture was stirred at RT for 30 minutes. The solvent was removed and the crude material 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-(difluoromethyl)benzonitrile trifluoroacetate (183 mg, 0.415 mmol, 84% yield) was used directly in the next step without purification. 1H NMR

Provenance & Evidence