HCID 178467394, compound → HCID 178467393, compound

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Reaction Steps

The title compound (0.055 g, 53%) was obtained as a white solid by MnO2 oxidation of 4-bromo-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-(1-hydroxyethyl)-1H-imidazole-5-carboxamide using a similar process to that described herein. 1H NMR (400 MHz, DMSO-d6) δ ppm 14.51 (br. s., 1H), 8.72-8.79 (m, 1H), 7.83 (s, 1H), 7.45-7.56 (m, 3H), 7.31-7.41 (m, 1H), 4.51 (br. s., 2H), 2.55 (s, 3 H). ES-LCMS: m/z 524.8, 526.8, 528.7 (M+1).

Provenance & Evidence