Dimethylformamide dimethyl acetal → ethyl 4-[(E)-dimethylaminomethylideneamino]-1H-imidazole-5-carboxylate

関与物質

反応手順

A solution of ethyl 4-amino-1H-imidazole-5-carboxylate (0.65 g, 4.19 mmol) and DMF-DMA (11.22 ml, 84 mmol) in DMF (3 mL) was stirred at RT under nitrogen for 3 days. The excess DMF-DMA and DMF were removed under vacuum to give the desired compound as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.34-13.68 (m, 1H), 8.09 (s, 1H), 7.36 (s, 1H), 4.12 (q, 2H), 2.96 (d, 6H), 1.22 (t, 3H).

情報源と証拠