Acetic Acid → HCID 70937102, compound

Participants

Reaction Steps

A 1M solution of TBAF (1.2 mL, 1.2 mmol) was neutralized with a drop of HOAc and added to a solution of 4-chloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-N-methyl-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-2-sulfonamide in THF (3 mL). The reaction mixture was stirred for 2 h at RT. Sat'd NaHCO3 was added and the aqueous phase was extracted with CH2Cl2. The combined organic phase was dried (Na2SO4), filtered, and evaporated to give 4-chloro-5-(hydroxymethyl)-N-methyl-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-2-sulfonamide as a light yellow oil that was used without purification and assumed to be quantitative.

Provenance & Evidence