2-Methyl-2-butene → HCID 70937195, compound

Participants

Reaction Steps

A solution of NaClO2 (0.21 g, 2.34 mmol) and NaH2PO4.H2O (0.19 g, 1.41 mmol) in H2O (0.5 mL) was added to a solution of 4-chloro-5-formyl-N-methyl-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-2-sulfonamide (0.083 g, 0.23 mmol) and 2-methyl-2-butene (1.41 mL of a 2M solution in THF, 2.81 mmol) in THF (0.70 mL) and t-BuOH (0.16 mL). The reaction mixture was stirred at RT for 1 h and extracted with EtOAc. The organic layer was dried (Na2SO4), filtered and dried to provide 4-chloro-2-[(methylamino)sulfonyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid as a clear oil that was assumed to be quantitative and used without further purification.

Provenance & Evidence