3-{[3-(Aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile → HCID 178486283, compound

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4-chloro-2-[(methylamino)sulfonyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid (0.12 mmol) and 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.040 g, 0.13 mmol) were employed using a procedure similar to that described herein to provide the title compound (0.034 g, 54%) as a white solid after deprotection and purification by Reverse-Phase HPLC (water:acetonitrile with 0.1% formic acid). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.55 (s, 1H), 7.40 (s, 2H), 7.27 (s, 1H), 7.24 (s, 1H), 4.63 (s, 2H), 2.70 (s, 3 H). ES-LCMS: m/z 532.1, 534.1, 536.0 (M+1).

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