3-{[3-(Aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile → HCID 178509952, compound

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2-(aminosulfonyl)-4-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid (0.26 mmol) and 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.089 g, 0.29 mmol) were employed using a procedure similar to that described herein to provide the title compound (0.055 g, 41%) as a white solid after deprotection and purification by Reverse-Phase HPLC (water:acetonitrile with 0.1% formic acid). 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.55 (t, 1H), 7.35-7.43 (m, 2H), 7.27 (t, J=2.0 Hz, 1H), 7.24 (s, 1H), 4.63 (s, 2H). ES-LCMS: m/z 516.0, 518.0, 519.9 (M−1).

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