Benzene → Benzophenone

Participants

Reaction Conditions

Reaction Steps

55.1 g (324.2 mmol) of a benzene compound represented by the above formula (11) was added dropwise to a dichloromethane solution (350 ml) of 51.8 g (388.6 mmol) of aluminum chloride and 45.6 g (324.3 mmol) of benzoyl chloride cooled to 0° C. After the end of addition, they were stirred for 2 hours. After the reaction, the reaction solution was washed in water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a benzophenone derivative represented by the following formula (22) as 63.1 g (230.4 mmol, yield rate of 71%) of a yellow solid.

Provenance & Evidence