HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Quinolinepropionic acid, 1,2,3,4-tetrahydro-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Dimethyl sulfoxide methanol | HCID 22036561 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Quinolinepropionic acid, 1,2,3,4-tetrahydro- | HCID 98707 | — |
Reaction Steps
A mixture of the corresponding acid (0.2 mmol), amine (0.2 mmol), triethylamine (28 μL, 0.2 mmol) and HATU (76 mg, 0.2 mmol) in pyridine (0.5 mL) was microwaved at 200° C. for 420 s. The reaction mixture was diluted with 50% DMSO/MeOH (0.5 mL), filtered and purified by HPLC (gradient of 10-99% CH3CN/water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309543B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-c48273967afd48f986e64499b1e1c099 |
| Source note | uspto-grants-2012_11 |