反应详情

0.5 g (2.7 mmol) tert. Butyl 3-amino-pyrrolidine-1-carboxylate are dissolved in 7 ml DCM, combined with 1.4 ml (10.1 mmol) TEA and 0.5 g (2.7 mmol) 5-chloro-thiophene-2-carboxylic acid chloride and stirred for one hour at RT. The reaction mixture is diluted with DCM and washed successively with dil. aqueous KHSO4 solution, sat. aqueous NaHCO3 solution and water. The combined organic phases are dried on sodium sulphate and evaporated to dryness i. vac.

1. washwashed successively with dil. aqueous KHSO4 solution, sat. aqueous NaHCO3 solution and water
2. customThe combined organic phases are dried on sodium sulphate
3. customevaporated to dryness i