HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chlorothiophene-2-carbonyl Chloride → tert. Butyl (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
| Reactant | tert-Butyl 3-amino-4-methoxypyrrolidine-1-carboxylate | HCID 20067140 | — |
| Product | tert. Butyl (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidine-1-carboxylate | HCID 72411070 | — |
Reaction Steps
Prepared analogously to Example 1a from tert. Butyl (3SR,4SR)-3-amino-4-methoxy-pyrrolidine-1-carboxylate (prepared analogously to Y. Tsuzuki et al. Tetrahedron Asymm. 2001, 12, 2989) and 5-chlorothiophene-2-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309542B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-3794f27c31a949ab9d37b95f9fc7b6a0 |
| Source note | uspto-grants-2012_11 |