反应详情

温度

70 °C

1.2 g (6.6 mmol) methyl 2,3-dihydro-1H-isoindole-5-carboxylate are dissolved in 5 ml formic acid, combined with 2 ml formalin solution (37% solution in water), heated to 70° C. for 3.5 hours and stirred for 16 hours at RT. The reaction mixture is evaporated down i. vac. and combined with 0.1 N sodium hydroxide solution and extracted three times with ethyl acetate. The combined organic phases are dried on sodium sulphate, filtered and evaporated down i. vac.

1. customThe reaction mixture is evaporated down i
2. extractionextracted three times with ethyl acetate
3. customThe combined organic phases are dried on sodium sulphate
4. filtrationfiltered
5. customevaporated down i