Trifluoroacetate → 6-methyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-2-carboxylic acid

HRID 1875336Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[S:10][C:4]=2[CH2:3]1.FC(F)(F)C([O-])=O>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:4]=2[CH2:3]1

Participants

Reactant 2

HCID 84468Trifluoroacetate

HCID 58157676Methyl 6-methyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridine-2-carboxylate

Product 1

HCID 178425026-methyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-2-carboxylic acid

Procedure

Prepared analogously to Example 45b from methyl 6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-2-carboxylate (as the trifluoroacetate salt).

Sources & evidence

ORD record: ord-1a93376115ee4527ba01074e1bceeb63
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309542B2

Reaction notes

Loading…