Sodium borohydride → HCID 57423982, compound

HRID 1875353Notes

Reaction equation

HRID 1875353 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:9]2[S:10][CH:11]=[CH:12][C:8]=2[CH2:7][CH2:6][N:5]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH:4]1[C:9]2[S:10][CH:11]=[CH:12][C:8]=2[CH2:7][CH2:6][NH:5]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 57423981HCID 57423981, compound

Product 1

HCID 57423982HCID 57423982, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.0 g (5.5 mmol) 7-methoxymethyl-4,5-dihydro-thieno[2,3-c]pyridine are dissolved in 10 ml of methanol and combined batchwise with 0.4 g (11.0 mmol) sodium borohydride while cooling with an ice bath. The ice bath is removed and the reaction mixture is stirred at RT for two hours. Then it is evaporated down and reacted further as the crude product.

Workup

  1. temperaturewhile cooling with an ice bath
  2. customThe ice bath is removed
  3. customThen it is evaporated down
  4. customreacted further as the crude product

Sources & evidence

ORD record
ord-c7387a0454de4c818abbfc21e1d2c1f4
Source dataset
uspto-grants-2012_11
Patent number
US08309542B2

Reaction notes

Loading…