Ethyl isocyanate → HCID 131730052, compound

Participants

Reaction Steps

120.0 mg (0.3 mmol) tert. Butyl (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-2-hydroxymethyl-pyrrolidine-1-carboxylate are refluxed in 5 ml of toluene with 30 μl (0.38 mmol) ethylisocyanate for three hours. Then 100 μl ethyl isocyanate are added three times at three hour intervals and the mixture is refluxed for a further 16 hours. Then the mixture is cooled, evaporated to dryness and purified by flash chromatography on silica gel (eluant DCM/methanol 100:3).

Provenance & Evidence