Sodium Azide → HCID 86761676, compound

Participants

Reaction Conditions

Reaction Steps

330.0 mg (0.75 mmol) tert. Butyl (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-2-methanesulphonyloxymethyl-pyrrolidine-1-carboxylate are dissolved in 20 ml DMF and combined with 146.6 mg (2.3 mmol) sodium azide. The mixture is stirred at 50° C. for 16 hours. Then a further 73 mg (1.12 mmol) sodium azide are added and the mixture is stirred for a further two hours at 50° C. Then it is concentrated i. vac. The residue is combined with water/sat. Saline solution and extracted three times with ethyl acetate. The combined organic phases are dried on sodium sulphate, filtered and evaporated down i. vac.

Provenance & Evidence